The modified release matrix dosage form is preferred in order to avoid fluctuations in the blood levels, which was observed in the conventional dosage form of Nifedipine. The main objective of this study was to formulate sustain release pellet of Nifedipine and compress it into tablet as final dosage form. The drug has low half life of 2 hrs & it is rapidly eliminated. The Multiple Unit System retained in gastrointestinal tract (GIT) for more than 12 hrs and distributed throughout the GIT. Pellets were prepared by Extrusion and Spheronization technique using HPMC K4M as binder and evaluated for micromeritics property. Mixtures of Ethyl Cellulose & Eudragit RSPO were used as coating polymers in different concentrations. Polymer coated pellet were compacted into tablets with a blend of excipients comprising of Microcrystalline Cellulose. SEM photographs and in-vitro release profiles for compacted pellets showed no apparent damage to the coated pellets as a result of the compaction process. The physicochemical parameters of tablets were evaluated as per official methods. Formulated tablets show sustained in-vitro dissolution probably due to optimized concentrations of polymers.
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